The team would require additional funding to pursue clinical trials in humans. Dr. Anne Moscona, a pediatrician and microbiologist at Columbia and co-author of the study, said there was a patent on the product, and she hoped Columbia University would approach the federal government’s Operation Warp Speed or large pharmaceutical companies that are seeking new ways to combat the coronavirus.- Advertisement – The lipoprotein can be inexpensively produced as a freeze-dried white powder that does not need refrigeration, Dr. Moscona said. A doctor or pharmacist could mix the powder with sugar and water to produce a nasal spray.Other labs have designed antibodies and “mini-proteins” that also block the SARS-CoV-2 virus from entering cells, but these are chemically more complex and may need to be stored in cold temperatures.Dr. Moscona and Dr. Porotto have been collaborating on similar “fusion inhibitor” peptides for 15 years, they said in a conference call. They have developed some against measles, Nipah, parainfluenza and other viruses.But those products aroused little commercial interest, Dr. Porotto said, because an effective measles vaccine already exists and because the deadly Nipah virus only turns up occasionally in faraway places like Bangladesh and Malaysia.Monoclonal antibodies to the new coronavirus have been shown to prevent infection as well as treat it, but they are expensive to make, require refrigeration and must be injected. Australian scientists have tested a nasal spray against Covid-19 in ferrets, but it works by enhancing the immune system, not by targeting the virus directly.Because lipopeptides can be shipped as a dry powder, they could be used even in rural areas in poor countries that lack refrigeration, Dr. Moscona said.Dr. Moscona, a pediatrician who usually works on flu and other viruses that infect children, said she was most interested in getting the product to poor countries that may never have access to the monoclonal antibodies and mRNA vaccines that Americans may soon have. But she has little experience in that arena, she said. Dr. Peter J. Hotez, dean of the National School of Tropical Medicine at Baylor College of Medicine, said the therapy looked “really promising.”“What I’d like to know now is how easy it is to scale production,” he said.In the study, the spray was given to six ferrets, which were then divided into pairs and placed in three cages. Into each cage also went two ferrets that had been given a placebo spray and one ferret that had been deliberately infected with SARS-CoV-2 a day or two earlier.Ferrets are used by scientists studying flu, SARS and other respiratory diseases because they can catch viruses through the nose much as humans do, although they also infect each other by contact with feces or by scratching and biting.After 24 hours together, none of the sprayed ferrets caught the disease; all the placebo-group ferrets did.“Virus replication was completely blocked,” the authors wrote.The protective spray attaches to cells in the nose and lungs and lasts about 24 hours, Dr. Moscona said. “If it works this well in humans, you could sleep in a bed with someone infected or be with your infected kids and still be safe,” she said.The amino acids come from a stretch of the spike protein in coronaviruses that rarely mutates. The scientists tested it against four different variants of the virus, including both the well-known “Wuhan” and “Italian” strains, and also against the coronaviruses that cause SARS and MERS.In cell cultures, it protected completely against all strains of the pandemic virus, fairly well against SARS and partially against MERS. The work was described in a paper posted to the preprint server bioRxiv Thursday morning, and has been submitted to the journal Science for peer review. – Advertisement – The spray attacks the virus directly. It contains a lipopeptide, a cholesterol particle linked to a chain of amino acids, the building blocks of proteins. This particular lipopeptide exactly matches a stretch of amino acids in the spike protein of the virus, which the pathogen uses to attach to a human airway or lung cell.Before a virus can inject its RNA into a cell, the spike must effectively unzip, exposing two chains of amino acids, in order to fuse to the cell wall. As the spike zips back up to complete the process, the lipopeptide in the spray inserts itself, latching on to one of the spike’s amino acid chains and preventing the virus from attaching.“It is like you are zipping a zipper but you put another zipper inside, so the two sides cannot meet,” said Matteo Porotto, a microbiologist at Columbia University and one of the paper’s authors.- Advertisement – A nasal spray that blocks the absorption of the SARS-CoV-2 virus has completely protected ferrets it was tested on, according to a small study released on Thursday by an international team of scientists. The study, which was limited to animals and has not yet been peer-reviewed, was assessed by several health experts at the request of The New York Times.If the spray, which the scientists described as nontoxic and stable, is proved to work in humans, it could provide a new way of fighting the pandemic. A daily spritz up the nose would act like a vaccine.- Advertisement – “Having something new that works against the coronavirus is exciting,” said Dr. Arturo Casadevall, the chairman of immunology at the Johns Hopkins Bloomberg School of Public Health, who was not involved in the study. “I could imagine this being part of the arsenal.”The work has been underway for months by scientists from Columbia University Medical Center in New York, Erasmus Medical Center in the Netherlands, Cornell University in Ithaca, N.Y., and the University of Campania in Italy. The study was funded by the National Institutes of Health and the Columbia University Medical Center.
“And it’s easier for a whole lot of people,” after Mr. Trump’s defeat, he said. “If you’re Muslim in this country, you don’t have to worry that the president doesn’t want you here. If you’re an immigrant, you don’t have to worry if the president is going to be happy to have babies snatched away.”- Advertisement – “You spend so much of your life energy just trying to hold it together,” added Mr. Jones, who is Black. “And this is a big deal for us just to be able get some peace and have a chance for a reset.”Mr. Jones said that Mr. Trump had made it acceptable to show “racism” overtly, and said he feared for his family’s safety under his presidency. – Advertisement – As thousands of people cheered, danced and honked their horns in New York, Philadelphia and Atlanta, Mr. Jones summed up the feelings of many Trump critics, overcome with relief that Mr. Trump had been vanquished.“This is vindication for a lot of people who really have suffered,” he said, as he began to sob. “It is a good day for this county. I am sorry for the people who lost, but for most, this is a good day.” Mr. Jones’s opinion was not universally shared, not even on CNN’s set.- Advertisement – Former Representative Rick Santorum of Pennsylvania, a Republican, questioned calling the race in his home state until all provisional ballots were tallied, saying the race was “not over.” The election of Joseph R. Biden Jr. elicited powerful reactions across the nation but few are resonating as deeply as the emotional on-air response to President Trump’s defeat by the CNN contributor Van Jones — who invoked George Floyd’s dying words in expressing his sense of relief and vindication.“‘I can’t breathe’ — that wasn’t just George Floyd, that was a lot of people who felt they couldn’t breathe,” said Mr. Jones, a former Obama administration official, breaking down in tears moments after the network called the race for Mr. Biden.- Advertisement –
Thanksgiving is just over two weeks away. Families, of course, want to be together. But college students, who have watched the virus rip through universities before radiating off campus, may pose a significant risk to their loved ones.As our colleague Shawn Hubler reports, many universities have planned to end in-person classes before the holiday and require students to finish the term remotely, partly to avoid an expected wave of cold-weather infections.- Advertisement – Remote learning woesMichelle Hainer wrote an honest, frustrated essay about the fatigue of parenting a remote-learner. She watches her kids snark to teachers and knows their peers see every room in their house. She watches her kids look for pencils, and knows her parenting style is on full display.“Before the coronavirus came into our collective lives, I was largely unaware of what my kids and their teachers did in school all day — and vice versa,” she wrote. “But now, those boundaries have become a thing of our pre-pandemic past.”Sign up here to get the briefing by email. Talk through your celebrationThis is going to be a strange year, even if you do get together with family in person. Talk through your family’s comfort level, and ask each individual how they stand. The most cautious person may get to set the agenda.“My family and I have very different comfort levels,” said Maddi Hundley, 19, a student at the University of Utah. “Case numbers are higher per capita where I attend school than at home, so the combination of their current lifestyle combined with the high cases numbers where I live makes me nervous.” When you are together, plan some way to give thanks on purpose. That might be over Zoom or email if you’re not together. But even if hugging is a no-go, we still need to be together somehow this year.Even in the best of times, family tensions tend to flare over Thanksgiving. If that happens, remember that none of this is your fault, nor is it your family’s fault. So carve the turkey (or the tofurkey!) and find togetherness however you can.Fears after a football gameThis weekend, the University of Notre Dame beat Clemson University at a highly anticipated football game. Fans promptly stormed the field. We’ve decide to talk about Thanksgiving now, just over two weeks before the actual holiday, to give you a framework to plan with your family. We also wanted to give you a sense of what other students are feeling.Testing is crucialTo reduce the risk of students carrying the coronavirus home for the holidays, some colleges and universities are requiring students to test negative for the virus before they can leave campus. Cases are rising at Arizona State University, but university officials said around half of on-campus students have not complied with random testing. But many schools — including Pennsylvania State University and Indiana University — are not making the testing mandatory for all students.In Massachusetts, where cases have been surging, Boston University has asked students not to leave campus until Dec. 10, when classes end. “We are saying, ‘Stay here,’ plain and simple,” said Kenneth Elmore, the associate provost and dean of students.Epidemiologists recommend that travelers isolate themselves before traveling for at least a week and receive one or more negative coronavirus tests within three days of departure. Upon arrival, travelers should again quarantine until receiving one or more negative test results over three days.- Advertisement – K-12 update A good read: After Harvard’s president Lawrence S. Bacow tested positive, he said he and his wife had been “completely isolated in the house.” In fact, The Harvard Crimson reported, two university custodians had continued to clean their home for four hours, twice a week, well after the university shut down in March. Still, the team mostly cleared the field after the victory. That was thanks to advance planning from Notre Dame’s coach, Brian Kelly. “I just want you to know,” he told his team, “When we win this thing, the fans are going to storm the field.”Around the countryCollege update Although she plans to wear an N-95 mask and face shield for the whole 18-hour journey, she’s still worried.“I honestly won’t be surprised if I get the virus during my travel,” she said. Once she arrives, she plans to quarantine for at least five days. “My worst fear is coming home and getting the virus while traveling,” said Maximilian King, 21, a student at McGill University in Montreal who plans to quarantine for two weeks. If you have to fly, take precautions on the plane and in the airport. If you’re able to drive, most experts agre that a car will be safer than public transportation.Either way, start planning your travel now. And if you can, consider heading home a week early to split up your quarantine.An infection can take up to 14 days to show itself, so it’s not enough to test negative at school and then travel home, intending to join a family celebration a day or two later.“Their arrival on Wednesday with plans to see grandma on Thursday could pose a huge risk,” said David Rubin, a pediatrician and public health expert at the University of Pennsylvania. – Advertisement – Those who do not test should quarantine for 14 days before and after traveling.Map out your travelStella Tallmon, 18, will be heading home to Alaska all the way from Kenyon College in Ohio. New York State’s university system will require “all students using on-campus facilities in any capacity” — about 140,000 students in all — to test negative for the virus within 10 days of their departure, and to quarantine according to county health rules if they test positive.- Advertisement –
And at the University of Southern California, where classes, which are all remote, are scheduled to end on Friday, the coronavirus dashboard showed a positivity rate of nearly 8 percent and a spike of 50 new cases among students. U.S.C.’s chief health officer, Dr. Sarah Van Orman, said the flare-up stemmed largely from study groups and other small gatherings in private off-campus apartments. At least one case, however, was a member of the women’s basketball team, whose positive test prompted the quarantine of the entire roster this week.The virus has underscored the sheer scale of the economic and public health challenge in California. The food program at the Los Angeles public school system, which serves some 700,000 mostly low-income students scattered over more than 700 square miles, has already evolved into the largest school-based relief effort in the United States. “Let us remember that no matter how we feel, we all have an obligation to protect each other from Covid-19,” Barbara Ferrer, the county’s director of public health, said in the notice. “Gathering with people outside of your household, especially in settings where people are shouting, chanting or singing and not distancing can easily lead to increased cases of Covid-19.”In Los Angeles County, case counts have shot up even in communities that have made a priority of controlling the virus. Colleges have pivoted almost entirely to remote instruction in California, allowing only a small fraction of the usual number of students to live in campus housing, where most have been intensively tested.No matter. At the University of California, Los Angeles — which has closed its campus to all but essential visits and limited dorm occupancy to 5 percent of the normal level — an off-campus Halloween party left 29 students infected and in isolation this week, said Ricardo Vazquez, a university spokesman. At Claremont McKenna College, where campus housing has been closed, health authorities this week emailed students to warn that several of them had tested positive after parties in the nearby Inland Empire.- Advertisement – Even though the sustained decline in hospitalizations of coronavirus patients since late July has reversed, California still has ample room in its hospitals. On Thursday, 3,987 people in the state were hospitalized with the virus, a 32 percent increase from two weeks ago.Public health officials in Los Angeles County were alarmed on Saturday after jubilant residents flooded the streets when the presidential election was called for Joseph R. Biden Jr. Worried the spontaneous celebrations could become superspreader events, the department of public health posted a notice recommending that celebrations take place over “virtual platforms.”- Advertisement – – Advertisement –
– Advertisement – The royal added, “Like the threatened red squirrels collecting their hazelnuts or jays their seeds and acorns, we must be wise and far-sighted. We have a very short window of opportunity, which must not be squandered, in which to seize something good from this crisis and, as we rebuild, to put nature, our planet and our children and grandchildren first.”Charles tested positive for coronavirus in March after “displaying mild symptoms.” He told Sky News in June that he was “lucky” his diagnosis wasn’t more severe.“I’ve had it and can still understand what other people are going through,” he said at the time. “I feel particularly for those, for instance, who’ve lost their loved ones but were unable to be with them at the time. That’s, to me, the most ghastly thing. But in order to prevent this from happening to so many more people, this is why I’m determined to find a way out of this.”Listen to Us Weekly’s Hot Hollywood as each week the editors of Us break down the hottest entertainment news stories! “Wishing The Prince of Wales a very happy birthday today!” she captioned the post.Charles’ son Prince William and his daughter-in-law Duchess Kate also wished him a happy birthday from their Instagram account. “Wishing a very Happy Birthday to His Royal Highness The Prince of Wales! 🎂” the Duke and Duchess of Cambridge, both 38, captioned a photo of Charles smiling.Charles responded to the tributes via the Clarence House Instagram page, which posted a photo of him wearing a green tartan Scottish kilt. “Thank you for all the well wishes on The Prince of Wales’s 72nd Birthday!” the post read.Prince Charles and Queen Elizabeth II. Shutterstock- Advertisement – Charles celebrated his birthday earlier this week when he served as a guest editor for Country Life magazine. The prince penned an op-ed encouraging people to remain positive in the face of the coronavirus pandemic.“The country, and the world, have experienced changes we could never have foreseen,” he wrote. “Uncertainty has become a steady state; the previously unimaginable has become unexceptional; the extraordinary has become normal. At such a time, it is tempting, and understandable, to focus on the losses, the failures and the challenges. However, if the life of the land teaches anything, it is the need to look at the long term.”- Advertisement – Still her little boy! Queen Elizabeth II took a trip down memory lane when she paid tribute to Prince Charles on his 72nd birthday.The queen, 94, shared a black-and-white photo via Instagram on Saturday, November 14, which featured herself holding the Prince of Wales when he was an infant. She also posted a recent picture of the duo smiling at each other while they attended the 2016 Braemar Gathering, an annual sporting event, in Scotland.- Advertisement –
NFL Sunday: Week 10 as it happened- Advertisement –
See also: NIAID press release As the PNAS article notes, “There are presently no vaccines or approved therapeutics for NiV or HeV infection.” Knowing both the viral and cell proteins involved in fusion will allow scientists to develop vaccines and treatments for these two important emerging infectious diseases. Both groups highlighted the close concordance between patterns of Ephrin-B2 expression and sites of infection. “EphrinB2 is essential for vasculogenesis and axonal guidance, and is expressed on endothelial cells, neurons and smooth muscle cells surrounding small arteries and arteriolesan expression pattern highly concordant with the known cellular tropism of NiV,” the Nature report says. The UCLA group’s findings are detailed in a Jul 6 online publication in Nature. Dr. Lee and colleagues utilized the NiV attachment glycoprotein (G) responsible for host cell fusion in an immunoprecipitation assay. They found that G pulled down a 48kD protein from the surface of susceptible, but not resistant, cells. Using trypsin digestion and mass spectrometry, they identified the protein as Ephrin-B2. Proceedings of the National Academy of Sciences published the USUHS group’s findings online Jul 5. The authors had previously identified a human cell line not susceptible to infection by NiV or HeV. Using microchips embedded with thousands of candidate genes, they compared genes expressed in this resistant cell line to those in cell lines susceptible to viral infection. Twenty-one candidate genes were expressed only in the susceptible cell lines and from this group, the researchers identified the 10 genes expressed most strongly in the susceptible cells. These were transfected individually into the resistant cell line; only Ephrin-B2 caused the resistant cells to become susceptible to infection. The two groups also pointed out the conserved nature of the Ephrin family of cell surface proteins and noted that this could explain the broad range of species susceptible to infection by Nipah and Hendra viruses. Observing that NiV and HeV have been documented in flying foxes, the PNAS article says, “It will be of interest to determine whether [Ephrin-B2] serves as the virus receptor in these natural animal hosts.” CIDRAP Overview on Nipah virus Bonaparte MI, Dimitrov AS, Bossart KN, et al. Ephrin-B2 ligand is a functional receptor for Hendra virus and Nipah virus. Proc Natl Acad Sci 2005 (published online Jul 5) [Full text] Jul 19, 2005 (CIDRAP News) Two groups have independently published the identity of the human protein that facilitates infection by the Nipah and Hendra viruses. First recognized in the mid-1990s, these two emerging infectious animal diseases, which are transmissible to humans, are considered possible bioterror agents. A Malaysian outbreak of respiratory infections among pigs in 1998 spread to nearly 370 people in the form of a viral encephalitis, killing 105. The identified viral pathogen, named Nipah virus (NiV), was also classified as a paramyxovirus. In 1994, 15 horses and two humans near Brisbane, Australia, presented with fatal acute respiratory disease. The etiologic agent was named Hendra virus (HeV) and classified in a new genus of the viral family Paramyxoviridae. Though the viral proteins responsible for attachment were identified, no one had yet found the receptor that allows Nipah and Hendra viruses to enter host cells. The new studies point to a cell surface protein, Ephrin-B2, as the mechanism for entry. The protein is present in humans, horses, pigs, bats, and other mammals a finding consistent with the wide range of animals susceptible to Nipah and Hendra infection. A team led by Christopher Broder, PhD, at the Uniformed Services University of the Health Sciences (USUHS) utilized a microarray screen to narrow down the possible receptors. Working independently, Benhur Lee, MD, and colleagues at the University of CaliforniaLos Angeles (UCLA) identified the receptor using an immunoprecipitation strategy. Negrete OA, Levroney EL, Aguilar HC, et al. EphrinB2 is the entry receptor for Nipah virus, an emergent deadly paramyxovirus. (Letter) Nature 2005 (published online Jul 6) [Abstract] Both studies were funded by the National Institute of Allergy and Infectious Diseases (NIAID).
Mar 30, 2009 (CIDRAP News) – The US Food and Drug Administration (FDA) today warned consumers to avoid eating pistachios after a California producer recalled 1 million pounds of its product because of tests by a food company that showed contamination with four different Salmonella strains.David Acheson, MD, associate commissioner for foods at the FDA, emphasized at a media briefing this evening that no illnesses have been linked to the outbreak and that the advice to consumers is a proactive move to prevent illnesses while the FDA tracks the distribution of the pistachios. They were produced by Setton Farms, based in Terra Bella, Calif., the nation’s second largest supplier of domestically grown pistachios.”We’re getting out ahead of the curve. This recall was triggered by sampling in the food industry,” Acheson said, commending Kraft Foods for identifying the contamination through routine rigorous testing and notifying the FDA of its findings on Mar 24. Kraft recalled its Back to Nature Nantucket Blend trail mix, which contains pistachios, on Mar 25. Two days later, Kroger Corp. recalled 10-ounce containers of its Private Selection shelled pistachios, sold in 31 states.Acheson said that though the pistachio recall is unrelated to the recent Salmonella outbreak linked to the Peanut Corporation of America (PCA), he predicted that the number of product recalls might rival the PCA outbreak, because pistachios—like peanuts—are used as an ingredient in such a wide array of food products. The FDA will add interactive tools to its Web site to help consumers manage the volume of pistachio recall information.Acheson advised consumers to hold onto their pistachio products until more details are known about the distribution of the recalled pistachios. He said FDA and California investigators at the facility are examining supply-chain and distribution records and that the California Department of Public Health has collected hundreds of environmental samples.Jeff Farrar, food and drug chief of the California Department of Health Services (CDHS), told reporters that the recall covers Setton Farms’ 2008 crop year. “The firm has been cooperative, even turning around trucks that are in transit,” he said.Though no illnesses have been directly linked to the Salmonella contamination in pistachios, Acheson said the FDA has received at least two consumer complaints, one from the East Coast and one from the West Coast.The FDA said the four Salmonella enterica serotypes identified in testing conducted by Kraft are Montevideo, Newport, Senftenberg, and Larochelle.Acheson said the FDA is working closely with the Centers for Disease Control and Prevention (CDC) to determine if any of the isolates are linked to any illnesses.The pistachios distributed by Setton Farms are roasted, which typically represents a kill step for Salmonella organisms, Acheson said, adding that cross-contamination, environmental contamination, or a flaw in the roasting process could have tainted the pistachios. The company distributes bulk roasted pistachios to about 35 wholesalers that repack the products and distribute them to other companies.See also:Mar 25 Georgia Nut recall noticeMar 25 Kraft press releaseMar 27 Kroger pistachio recall
The flat tax per bed this year will amount to HRK 300 (A class), while the sojourn tax for persons providing household accommodation services will amount to HRK 345 (A class). Payment slips can be downloaded from the system, and at the end of the calendar year it is necessary to print the Guest List. In order to achieve excellent results this year as well, the Tourist Board reminds its renters of numerous activities and news. The Apoxyomenos Museum has prepared special packages for renters of 10 tickets for 100 kuna and 20 pieces for 200 kuna, which can be a great gift for guests of the accommodation. Also, the Lošinj Museum offers renters free admission every Saturday during March with expert guidance from 10 am to 12 noon. This year, the Tourist Board will co-finance investments in marketing activities such as photography, interior and exterior videos, apartment design, family accommodation management software, media advertising, promotional materials, etc. Also, the Tourist Board has prepared a promotional photo archive of the destination. taken over at the Tourist Office. In cooperation with foreign language schools, foreign language courses will be organized and co-financed for renters and members of their families. Mali Lošinj continues to implement the project “IQM – Integrated Quality Management” in the destination and Cvitković emphasizes that renters are encouraged to implement IQM standards. “We are preparing a brochure IQM Lošinj (integrated quality management in the destination) in which the project participants will present 76 of them, including 36 renters, and the goal is to network all stakeholders in tourism that implement IQM standards in their sector and can guarantee additional quality guests. As this is a pilot project, we expect in the coming years to include a larger number of renters who will be an example to others how only by investing in raising quality can achieve better physical results of tourist traffic.” The importance of private accommodation in Mali Lošinj is indicated by the excellent numbers. “Out of a total of 2.372.329 overnight stays on Lošinj in 2018, as much as 18,5% were realized in private accommodation. Given the significant share of private accommodation in total overnight stays in the destination, joint activities contribute to increasing the competitiveness and quality of the tourist offer of the island of Losinj”, Said Cvitkovic. Apoxyomenos Museum The question is whether these activities will stimulate and influence the additional expansion of private accommodation in Mali Lošinj. “The activities we have for renters are primarily intended to raise the quality of private accommodation and higher capacity utilization, which in private accommodation is 19% while for example in hotel accommodation at 41%, campsites 24%. I am of the opinion that the activities we carry out will not increase the number of renters, accordingly we have been carrying out activities for years and we do not have major increases in the number of accommodation capacities in private accommodation. Compared to 2017, we have an increase in beds in private accommodation from 6.183 to 6.417 (4%), which is a trend that is present throughout Croatia and which has no direct connection with the benefits we have with landlords, mostly about the categorization of accommodation for holidays”, Is the opinion of Cvitković. The professional education of the cultural-historical and natural heritage of the Cres-Lošinj archipelago called “Small Heritage School” is intended for everyone who wants to renew their knowledge or learn something new about the area where they live and work, especially those who are in direct contact with tourists. The Tourist Board will co-finance 50 percent of the training for all interested renters. “Every year we do several trainings for landlords in agreement with their representatives in the Assembly and the Council of the Tourist Board, this year as part of the Forum of Lošinj landlords “Innovative private” we do trainings “Go digital” – social networks, interior design, gardening and gardening, working online travel agencies”, Said Dalibor Cvitković, director of the Tourist Board of the City of Mali Lošinj. The Tourist Board of the City of Mali Lošinj has published data according to which in the past 2018, 3 percent more arrivals and 2 percent more overnight stays were realized on Lošinj, which ranked this destination of health and vitality among the leading Croatian destinations with the most overnight stays. Also, a two-day forum called “Innovative Private” will be organized from April 2 to 4 at the Hotel Aurora, in order to present tourist novelties to renters. The forum will also distribute bags for selective waste separation, to the package of which each renter is entitled per accommodation unit. A Flower Fair will be organized on April 6 in Malološinj Square, where citizens will be awarded flower seedlings. Every landlord has the right to a “Landlord Card” which offers a number of benefits when shopping in stores in the area of Mali Lošinj, but also the use of various services. RELATED NEWS:
The total number of aircraft landings and take-offs at airports in February 2019 was 4, which is an increase of 442% compared to February 2018. The largest passenger traffic was generated by Zagreb Airport with 179 thousand passengers (an increase of 5,8% compared to February 2018), followed by Dubrovnik Airport with 34 thousand passengers (an increase of 39,0% compared to February 2018) and the airport Split with 33 thousand passengers (an increase of 13,7% compared to February 2018). In February 2019, Croatian airports recorded 252 thousand passengers or 9,9% more than in the same month last year, according to data from the Central Bureau of Statistics (CBS). The most significant international passenger traffic was realized with German airports, 72 thousand passengers, which is an increase of 17,9% compared to the same period last year.